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Volume 3, Number 3, September 2016

This article reports the development of biodegradable photoluminescent polymer (BPLP)-based nanoparticles (NPs) incorporating either magnetic nanoparticles (BPLP-MNPs) or gadopentate dimeglumine (BPLP-Gd NPs), for cancer diagnosis and treatment. The aim of the study is to compare these nanoparticles in terms of their surface properties, fluorescence intensities, MR imaging capabilities, and in vitro characteristics to choose the most promising dual-imaging nanoprobe. Results indicate that BPLP-MNPs and BPLP-Gd NPs had a size of 195

Key Words
nanoparticles; fluorescent; MRI; contrast agent; dual imaging

Jyothi U. Menon, Parth Jadeja, Pranjali Tambe, Dheeraj Thakore and Kytai T. Nguyen: Bioengineering Department, The University of Texas at Arlington, Arlington, TX, USA 76019

Jyothi U. Menon, Parth Jadeja, Pranjali Tambe, Dheeraj Thakore and Kytai T. Nguyen:Graduate Biomedical Engineering Program, UT Southwestern Medical Center, Dallas, TX, USA 75390

Shanrong Zhang and Masaya Takahashi: Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA 75390

Zhiwei Xie and Jian Yang: Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802

Two-dimensional (2D) cell culture and in vivo cancer model systems have been used to understand cancer biology and develop drug delivery systems for cancer therapy. Although cell culture and in vivo model studies have provided critical contribution about disease mechanism, these models present important problems. 2D tissue culture models lack of three dimensional (3D) structure, while animal models are expensive, time consuming, and inadequate to reflect human tumor biology. Up to the present, scaffolds and 3D matrices have been used for many different clinical applications in regenerative medicine such as heart valves, corneal implants and artificial cartilage. While tissue engineering has focused on clinical applications in regenerative medicine, scaffolds can be used in in vitro tumor models to better understand tumor relapse and metastasis. Because 3D in vitro models can partially mimic the tumor microenvironment as follows. This review focuses on different scaffold production techniques and polymer types for tumor model applications in cancer tissue engineering and reports recent studies about in vitro 3D polymeric tumor models including breast, ewing sarcoma, pancreas, oral, prostate and brain cancers.

Key Words
polymeric scaffolds; 3D tumor models; cancer tissue engineering; in vitro cancer research

Seda Ceylan and Nimet Bolgen: Mersin University, Engineering Faculty, Chemical Engineering Department, Mersin, Turkey

Seda Ceylan: Adana Science and Technology University, Bioengineering Department, Adana, Turkey

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