Abstract
Magnetic nanoparticle based bioseparation in microfluidics is a multiphysics phenomenon that involves interplay of various parameters. The ability to understand the dynamics of these parameters is a prerequisite for designing and developing more efficient magnetic cell/bio-particle separation systems. Therefore, in this work proof-of-concept experiments are combined with advanced numerical simulation to design and optimize the capturing process of magnetic nanoparticles responsible for efficient microfluidic bioseparation. A low cost generic microfluidic platform was developed using a novel micromolding method that can be done without a clean room techniques and at much lower cost and time. Parametric analysis using both experiments and theoretical predictions were performed. It was found that flow rate and magnetic field strength greatly influence the transport of magnetic nanoparticles in the microchannel and control the capturing efficiency. The results from mathematical model agree very well with experiments. The model further demonstrated that a 12% increase in capturing efficiency can be achieved by introducing of iron-grooved bar in the microfluidic setup that resulted in increase in magnetic field gradient. The numerical simulations were helpful in testing and optimizing key design parameters. Overall, this work demonstrated that a simple low cost experimental proof-of-concept setup can be synchronized with advanced numerical simulation not only to enhance the functional performance of magneto-fluidic capturing systems but also to efficiently design and develop microfluidic bioseparation systems for biomedical applications.
Key Words
microfluidics; magnetic nanoparticles; bioseparation; lab-on-a-chip; mathematical modelin
Address
Ahsan Munir, Zanzan Zhu and H. Susan Zhou : Department of Chemical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, Massachusetts 01609, USA
Jianlong Wang : College of Food Science & Engineering, Northwest A&F University, 28 Xinong Road,Yangling,
Shaanxi 712100, China
Abstract
In this article, a smart multifunctional optical system-on-a-chip (SOC) sensor platform is presented and its application for fiber Bragg grating (FBG) sensor interrogation in optical sensor networks is investigated. The smart SOC sensor platform consists of a superluminescent diode as a broadband source, a tunable microelectromechanical system (MEMS) based Fabry-Perot filter, photodetectors, and an integrated microcontroller for data acquisition, processing, and communication. Integrated with a wireless sensor network (WSN) module in a compact package, a smart optical sensor node is developed. The smart multifunctional sensor platform has the capability of interrogating different types of optical fiber sensors, including Fabry-Perot sensors and Bragg grating sensors. As a case study, the smart optical sensor platform is demonstrated to interrogate multiplexed FBG strain sensors. A time domain signal processing method is used to obtain the Bragg wavelength shift of two FBG strain sensors through sweeping the MEMS tunable Fabry-Perot filter. A tuning range of 46 nm and a tuning speed of 10 Hz are achieved. The smart optical sensor platform will open doors to many applications that require high performance optical WSNs.
Address
C. Pang, M. Yu and A.K. Gupta : Department of Mechanical Engineering, University of Maryland, College Park, USA
K.M. Bryden: Department of Mechanical Engineering, Iowa State University, Ames, USA
Abstract
Concrete is known as a heterogeneous product which is composed of complex chemical composition and reaction. The development of concrete thermal effect during early age is critical on its future structural health and long term durability. When cement is mixed with water, the exothermic chemical reaction generates hydration heat, which raises the temperature within the concrete. Consequently, cracking may occur if the concrete temperature rises too high or if there is a large temperature difference between the interior and the exterior of concrete structures during early age hydration. This paper describes the contribution of novel Fabry-Perot (FP) fiber optic temperature sensors to investigate the thermal effects of concrete hydration process. Concrete specimens were manufactured under various water-to-cement (w/c) ratios from 0.40 to 0.60. During the first 24 hours of concreting, two FP fiber optic temperature sensors were inserted into concrete specimens with the protection of copper tubing to monitor the surface and core temperature change. The experimental results revealed effects of w/c ratios on surface and core temperature developments during early age hydration, as well as demonstrating that FP fiber optic sensors are capable of capturing temperature variation in the concrete with reliable performance. Temperature profiles are used for calculating the apparent activation energy (Ea) and the heat of hydration (H(t)) of concrete, which can help us to better understand cement hydration.
Key Words
structural health monitoring; concrete hydration; water-to-cement ratio; fiber optic temperature sensor; Fabry-Perot
Address
Xiaotian Zou and Xingwei Wang : Department of Biomedical Engineering and Biotechnology, University of Massachusetts,
Lowell, Massachusetts 01854-2827, USA
Alice Chao and Tzu-Yang Yu : Department of Civil and Environmental Engineering, University of Massachusetts,
Lowell, Massachusetts 01854-2827, USA
Nan Wu, Ye Tian and Xingwei Wang : Department of Electrical and Computer Engineering, University of Massachusetts, Lowell, Massachusetts 01854-2827, USA
Abstract
Structural health monitoring (SHM) is vital for detecting the onset of damage and for preventing catastrophic failure of civil infrastructure systems. In particular, piezoelectric transducers have the ability to excite and actively interrogate structures (e.g., using surface waves) while measuring their response for sensing and damage detection. In fact, piezoelectric transducers such as lead zirconate titanate (PZT) and poly(vinylidene fluoride) (PVDF) have been used for various laboratory/field tests and possess significant advantages as compared to visual inspection and vibration-based methods, to name a few. However, PZTs are inherently brittle, and PVDF films do not possess high piezoelectricity, thereby limiting each of these devices to certain specific applications. The objective of this study is to design, characterize, and validate piezoelectric nanocomposites consisting of zinc oxide (ZnO) nanoparticles assembled in a PVDF copolymer matrix for sensing and SHM applications. These films provide greater mechanical flexibility as compared to PZTs, yet possess enhanced piezoelectricity as compared to pristine PVDF copolymers. This study started with spin coating dispersed ZnO- and PVDF-TrFE-based solutions to fabricate the piezoelectric nanocomposites. The concentration of ZnO nanoparticles was varied from 0 to 20 wt.% (in 5 % increments) to determine their influence on bulk film piezoelectricity. Second, their electric polarization responses were obtained for quantifying thin film remnant polarization, which is directly correlated to piezoelectricity. Based on these results, the films were poled (at 50 MV-m-1) to permanently align their electrical domains and to enhance their bulk film piezoelectricity. Then, a series of hammer impact tests were conducted, and the voltage generated by poled ZnO-based thin films was compared to commercially poled PVDF copolymer thin films. The hammer impact tests showed comparable results between the prototype and commercial samples, and increasing ZnO content provided enhanced piezoelectric performance. Lastly, the films were further validated for sensing using different energy levels of hammer impact, different distances between the impact locations and the film electrodes, and cantilever free vibration testing for dynamic strain sensing.
Address
John S. Dodds and Kenneth J. Loh : Department of Civil & Environmental Engineering, University of California, Davis, CA 95616, USA
Frederick N. Meyers : Department of Mechanical & Aerospace Engineering, University of California, Davis, CA 95616, USA
Abstract
Nine deoxyribonucleic acid (DNA) sequences were used to functionalize single-walled carbon nanotube (SWNT) sensors to detect the trace amount of methanol, acetone, and HCl in vapor. DNA 24 Ma (24 randomly arranged nitrogenous bases with one amine at each end of it) decorated SWNT sensor and DNA 24 A (only adenine (A) base with a length of 24) decorated SWNT sensor have demonstrated the largest sensing responses towards acetone and HCl, respectively. On the other hand, for the DNA GT decorated SWNT sensors with different sequence lengths, the optimum DNA sequence length for acetone and HCl sensing is 32 and 8, separately. The detection of methanol, acetone, and HCl have identified that DNA functionalized SWNT sensors exhibit great selectivity, sensitivity, and repeatability with an accuracy of more than 90%. Further, a sensor array composed of SWNT functionalized with various DNA sequences was utilized to identify acetone and HCl through pattern recognition. The sensor array is a combination of four different DNA functionalized SWNT sensors and two bare SWNT sensors (work as reference). This wireless sensing system has enabled real-time gas monitoring and air quality assurance for safety and security.
Key Words
DNA-SWNT sensor; wireless sensor array; gas monitoring; pattern recognition
Address
Wenjun Zhang and L Wang : Department of Civil & Environmental Engineering, Northeastern University, 360 Huntington Ave,Boston, MA, U.S.A. 02115
Yu Liu : Department of Electrical &Computer Engineering, Northeastern University, 360 Huntington Ave,
Boston, MA, U.S.A. 02115
